GSH-Px活性与云南省地方性猝死关系的研究

Study on relationship between GSH-Px activity and Yunnan endemic sudden cardiac death

目的研究云南省地方性猝死病例组与谷胱甘肽过氧化物酶(GSH-Px)活性的关系,为云南省地方性猝死的预防提供依据。方法现场调查病区大姚县、景东县、南涧县、宁蒗县及非病区大理县,采用GSH-Px活力测试盒检测患者25例、对照107例的GSH-Px活性。结果病例组GSH-Px活性高于外对照组(P<0.05);大姚县、景东县GSH-Px活性高于外对照大理县(P<0.05);宁蒗县低于大理县;宁蒗县补硒前后两次检测结果为补硒后GSH-Px活性较补硒前高(P<0.05)。结论GSH-Px活性与云南省地方性猝死的发生可能存在一定程度的相关。

Objective To study the difference of glutathione peroxidase （GSH-Px） activity between the patients of the Yunnan endemic sudden cardiac death （YESCD） and controls in order to provide evidence for prevention. Methods Blood GSH-Px activity of YESCD patients and controls was determined. Results GSH-Px activity of patients of YESCD was higher than that of the external controls（P 〈 0.05）. GSH-Px activity of the disease area was higher than that of non-disease area （the external control（P 〈 0.05）. After supplement of selenium, GSH- Px activity of the subjects in Ninglang county increased （P 〈 0.05）. Conclusions GSH-Px activity is possibly related with YESCD to some extent.