血清前列腺特异性抗原与碱性磷酸酶测定在判断前列腺癌骨转移中的价值

Relationship of Serum Prostate-specific Antigen and Alkaline Phosphatase Levels with Bone Metastases in Patients with Prostate Cancer

目的:探讨血清前列腺特异性抗原(PSA)和碱性磷酸酶(ALP)水平与前列腺癌骨转移的关系。方法:回顾性分析96例前列腺癌患者的临床资料(其中29例伴有骨转移,67例不伴有骨转移)及患者血清PSA、ALP水平和骨扫描情况。结果:骨扫描阳性患者的血清PSA和ALP平均浓度均明显高于骨扫描阴性者(P<0.01)。PSA>20μg/L时骨扫描的阳性率明显高于PSA<20μg/L时骨扫描的阳性率(P<0.01)。ALP>90 U/L时骨扫描的阳性率明显高于ALP<90 U/L时骨扫描的阳性率(P<0.01)。结论:伴有骨转移的前列腺癌患者血清PSA和ALP水平均明显高于无骨转移者。当血清PSA>20μg/L和(或)ALP>90 U/L时应行骨扫描检查。

Objective： To investigate the relation of serum prostate-specific antigen （PSA） and alkaline phosphatase （ALP） levels to bone metastases in patients with prostate cancer. Methods ： We made a retrospective study of 96 cases of prostate cancer with （29 cases ） and without （67 cases ） bone metastases and evaluated their initial levels of serum PSA and ALP as well as the radionuclide bone scan findings. Results： The median concentrations of serum PSA and ALP were both in the bone scan-positive patients statistically higher than in those the negative ones （P 〈 0.01 ）. The percentages of the bone scan-positive patients with PSA 〉 20 μg/L or ALP 〉 90 U/L were also higher than those with PSA 〈 20 μg/L or ALP 〈 90 U/L （ P 〈 0.01 ）. Conclusion ： Prostate cancer patients with bone metastases have higher levels of PSA and ALP than those without. Radionuclide bone scan is necessary when the serum PSA level is 〉20 μg/L and/or ALP level 〉90 U/L. Natl J Androl,2005,11（11） ：825-827