摘要
目的:探讨应用吡柔比星(THP)进行膀胱内灌注预防膀胱癌术后复发的疗效和安全性.方法:对68例初发的浅表性膀胱癌术后患者定期进行THP膀胱内灌注治疗,随访18～48个月.结果:全组无肿瘤复发率为85.3%,复发率为14.7%,29例于膀胱灌注期间出现膀胱刺激症状,其中4例因为不能耐受,暂停灌注,其余患者均完成治疗.所有患者未见明显的全身性药物反应.结论:THP膀胱内灌注预防膀胱癌术后复发的疗效满意,病人耐受性好,无全身性给药的毒副反应.
Objective ：To investigate the effect of intravesical instillation of pirarubicin or mitomycin in the prophylaxis of local recurrence after resection of bladder cancer. Methods ：68 patients with bladder cancer after TURBT or partial cystectomy received intravesical instillation of pirarubicin. All these patients were followed up for 18 to 48 months. Results：Recurrence rate in the patients treated with pirarubicin was 14. 7%. No systemic side effect has been observed in all patients. Conclusion：Intravesical instillation of pirarubicin has been effective against local recurrence of bladder cancer without systemic side effects.
出处
《临床肿瘤学杂志》
CAS
2005年第2期157-158,160,共3页
Chinese Clinical Oncology
关键词
膀胱肿瘤
吡柔比星
膀胱灌注
Bladder neoplasms
Pirarubicin
Intravesical instillation
