小儿恶性肿瘤126例临床分析

Clinical Analysis of 126 Cases with Children Malignant Tumor

目的:回顾性分析该院小儿恶性实体肿瘤及血液肿瘤的临床资料,探讨其类型、病因、组织起源及扩散方式与成人间的差异.方法:对1993年～2004年该院各科收治的126例小儿实体肿瘤及血液肿瘤病例的性别、年龄、病理类型、临床分期及转移情况进行统计分析.结果:126 例中,男性82例,女性44例,男女比例1.86∶1;神经组织肿瘤56例,占44.4%;造血组织恶性肿瘤41例,占32.5%;胚胎性肿瘤41例,占32.5%;眼部视网膜母细胞瘤12例,占9.5%;骨恶性肿瘤 10 例,占7.9%;癌症类肿瘤5例,占4.0%. 该组实体肿瘤病例就诊时临床分期Ⅰ、Ⅱ期仅18.9%;神经母细胞瘤、肾母细胞瘤、畸胎瘤及横纹肌肉瘤临床就诊时多数已转移,已达Ⅲ、Ⅳ期(57.0%).结论:小儿恶性肿瘤的类型、病因、组织起源及扩散方式与成人有许多不同.

Objective：The clinical data of the children with parenchymal or hematic tumor were analyzed retrospectively in order to explore the differences between children and adults in its type, etiology, tissue origin and metastasis, iethods：126 hospitalized children with parenchymal or hematic tumor from 1993 to 2004 were analyzed statistically in gender, age, pathological type, clinical stage and metastasis. Results： Among the 126 cases, Male： female was 1. 86： 1. There were 56 cases originated from nervous tissue （44. 4% ）, 41 cases originated from hematogenic tissue （32.5%） ,41 cases originated from embryologic tissue（32. 5% ） , 12 cases of retinoblastoma （9. 5% ） , 10 cases of malignant tumor of bone （7.9%） , 5 cases originated from epithelial tissue. On seeing a doctor the patients on the stage Ⅰ and Ⅱ accounted for 18.9% , on the stage Ⅲ and Ⅳ accounted for 57. 0%. Conclusion：The differences between children and adults with parenchymal or hematic tumor were significant in its type, etiology, tissue origin and metastasis.