晚期结肠癌病人肠系膜淋巴结高内皮微静脉超微结构观察

The Ultrastructural Observation of High Endothelial Venules in the Mesenteric Lymph Node of Human's Terminal Colon Cancer

目的:探讨晚期结肠癌病人肠系膜淋巴结内高内皮微静脉超微结构的变化及其对淋巴细胞进入肠系膜淋巴结的影响。方法:采用透射电镜观察晚期结肠癌病人肠系膜淋巴结内高内皮微静脉的超微结构。结果:晚期结肠癌病人的肠系膜淋巴结内,高内皮微静脉管壁内皮细胞的细胞核出现大量齿状切迹,细胞膜出现大量指状突起。质膜小泡、Weibel-Palade小体、高尔基复合体减少,线粒体多出现肿胀、扩张,部分基膜不完整。高内皮微静脉管壁内少见淋巴细胞穿越。结论:晚期结肠癌病人肠系膜淋巴结内,高内皮微静脉的超微结构受到不同程度的影响和破坏,导致淋巴细胞进入肠系膜淋巴结的能力减弱。

Objective：To investigate the effects of high endothelial venuls in mesenteric lymph node on lymbocytes entrance mesenteric lymph node in patients with advanced colon cancer.Methods：The ultrastructure of high endothelial venules in mesenteric lymph node in patients with advanced colon carcen was observed by transmission electron microscope.Results：In the mesenteric lymph node of patients with advanced colon cancer,the nucleus of the endothelium appeared many tooh-like notch,and there were many finger-like prominence on the cell membrane surface in high endothelial venceles.Plasma membrane vesicle,weibed-plade body and Golgi complex body decreased,a large number of mitochondrion was swollen and expanded,a part of the basement membrane became disontinuous.The lymphocytes that got across the high endothelial venules lessened.Conclusion：In patients with advanced colon cancer the ultrastructure of high endothelial venules in the mesenteric lymph node was affected and destroyed in different extent and it lessened the ability by lymphocytes going to mesenteric lymph node.