^(99)锝~m-tetrofos min乳腺扫描鉴别乳腺包块性质的临床研究

A Clinical Study about ^(99)Tc^m-Tetrofosmin Imaging in Detection of Suspicious Palpable Breast Lesions

目的探讨99锝m-tetrofosmin乳腺扫描在鉴别可扪及的乳腺包块良恶性质方面的价值。方法2000年6月至2002年1月在我院临床发现乳腺包块的104例患者接受了99锝m-tetrofosmin乳腺扫描。检查时先经病变对侧肘静脉注射740 MBq显像剂,注射后5、10及20 min分别采集前位和侧位图像。距阵256×256,每帧记数1~1.5 M,将99锝m-tetrofosmin在乳房局部浓聚视为亲肿瘤显像阳性。全部病例以术后病理结果为金标准,以四格表进行评价分析。结果99锝m-tetrofosmin在对可扪及的乳腺包块性质进行鉴别诊断时,特异性为84%,敏感性为87%,准确性为86%,阳性预测值为85%,阴性预测值为86%。结论99锝m-tetrofosmin在对可扪及的乳腺包块进行良恶性质的鉴别时,不失为一种较为准确的方法。

Objective To assess the value of ^99Tc^m-Tetrofosmin imaging in discriminating malignant mass from benign breast mass. Methods From June 2000 to January 2002, 104 patients with breast mass detected by clinical examination were included. After 740 MBq ^99Tc^m-Tetrofosmin was injected intravenously in the contralateral arm to the breast lesion, the front and the lateral images were collected in 5 min, 10 rain and 20 min respectively. ^99Tc^m-Tetrofosmin imaging localized in breast was defined as the positive sign of affinitive tumor. All patients underwent operation within one week. Using histological assessment as a golden standard, the sensitivity, specificity, positive and negative predictive value for ^99Tc^m-Tetrofosmin SPECT of the breast were calculated respectively. Resuits The sensitivity of ^99Tc^m-Tetrofosmin imaging for discriminating between malignant mass and benign mass in palpable breast lesions was 87 %, specificity 84 %, positive and negative predictive value were 85 % and 86 % respectively. Conclusion The results suggested that ^99Tc^m-Tetrofosmin imaging is a valuable tool for distinguishing between malignant mass and benign mass in palpable breast lesions.