鼻咽癌、炎症、瘢痕组织的CT灌注研究

Analysis of CT Perfusion in Nasopharyngeal Cancer, Inflammatory and Scar Structure

目的 评价CT灌注成像对鼻咽癌、炎症、瘢痕组织的诊断价值。资料与方法66例进行了鼻咽部多排 螺旋CT(MDCT)灌注成像,其中正常对照组20例,鼻咽癌组25例,炎症组10例,鼻咽癌放疗后0．5-5年无复发病 例组(放疗后组)11例。在工作站应用去卷积计算局部组织的血流量(BF)、血容量(BV)、平均通过时间(MTT)、峰值 时间(TTP)、表面通透性(PS)图等,四组病例的四组数据用SPSS 11．0软件的独立样本t检验分析。结果 25例鼻 咽癌BF、PS、BV值明显高于其他组,有显著性差异。MTT值鼻咽癌组与其他组无显著性差异。炎症组与对照组比 较仅BF值有显著性差异。对照组与放疗后组比较无显著性差异。结论 本研究初步显示CT灌注成像可评价鼻 咽癌,其中BF、PS、BV意义最大,可与炎症、放疗后瘢痕组织鉴别;炎症组织的BF明显高于对照组。

Objective To evaluate the value of CT perfusion in the diagnosis of nasopharyngeal cancer, inflammation and scar structure, Materials and Methods 66 cases were performed with multi-detector CT perfusion study on nasopharynx, including 20 cases in control group. 25 cases with nasopharyngeal cancer, 11 cases after radiotherapy （without recurrence after 0. 5 - 5 years）, and 10 eases of inflammation. TTP, BF, BV, MTT and PS were analyzed with deconvolve algorithm. All data were analyzed staistieally by paired t test. Results BF, PS and BV value of nasopharyngeal cancer group were distinetly higher than others with statistically significance. There was no statistical significance in MTT value between nasopharyngeal group and other groups. Compared with control group, BF value of inflammatory group had statistical significance. No statistical significance was lonnd in all perfusion index between control group and post-radiation therapy group. Conclusion Primarily CT perfusion study could evaluate nasopharyngcal cancer with significantly BF, PS, and BV value, which could make differential diagnosis with inflammatory, post-radiation therapy scar strueture. BF value in inflammatory group is obviously higher than that in normal tissue.