钛-羟基磷灰石功能梯度材料骨内置入的扫描电镜研究

Scanning electron microscopic study of titanium-hydroxyapatite, the functionally graded-material implanted in rabbits

目的观察钛/羟基磷灰石功能梯度材料的生物相容性及与骨发生骨结合的发生。方法将钛(Ti)/羟基磷灰石(HA)功能梯度材料和纯HA、纯Ti分别置入兔颅骨中,用扫描电镜进行形态学方面的观察。结果钛/羟基磷灰石功能梯度材料置入后,置入体周围形成新骨的时间早,各个时期新骨形成的量,成熟程度与纯HA相似,而均较纯Ti好,2个月时FGM和纯HA的骨性界面已分不清,材料与宿主骨结合成一骨性整体。而纯Ti与宿主骨之间有少量空隙,界面仍较清晰。结论Ti/HAFGM其有良好的生物相容性,能与骨发生骨整合,早期骨整合与纯HA相似而优于纯Ti。

Objective The purpose of this study was to observe the tissue tolerance of Ti-HA functionally graded -material （FGM） and the form of the material-bone interface. Methods The sintered Ti -HA FGM, pure HA and pure Ti were respectively implanted into the parietal bone of rabbits. The specimens were observed by SEM at 2, 4, 8 postoperative weeks. Results In the early stage, the new bone surrounding the Ti -HA FGM formed earlier with larger amount and better maturity than the pure Ti. The condition was similar to the pure HA. Two months after the operation, direct bonding of material-bone interface was formed between the Ti -HA FGM and the new bone as an integral body. However, there was a little space left between the new bone and the pure Ti. Conclusions The Ti -HA FGM has good tissue tolerance. Its early integration with bone is similar to pure HA and better than pure Ti.