免增灵对小鼠红细胞免疫功能和NK细胞活性的影响

Influence of MianZeng-Ling on Mouse Erythrocyte Immunolo-gical Function and NK Cell Activity

背景与目的:研究免增灵对小鼠红细胞免疫功能和自然杀伤细胞(NatureKillercell,NK)活性的影响。材料与方法:采用RBC_CR1花环率、RBC_IC花环率、RBC_Ca花环率及NK细胞活性检测方法。结果:实验表明小鼠红细胞可以免疫粘附肿瘤细胞,小鼠经腹腔注射环磷酰胺后,红细胞免疫粘附肿瘤细胞的能力明显下降,而免增灵则能明显的对抗这一作用,使红细胞粘附肿瘤细胞的能力明显改善,其效果优于市售贞芪扶正颗粒剂。同样,免增灵可以对抗环磷酰胺降低小鼠NK细胞活性,改善和提高小鼠NK细胞活性。结论:免增灵能改善和提高环磷酰胺降低小鼠红细胞免疫功能和NK细胞活性的功能。

BACKGROUND ＆ AIM： To study the influence of Mian-Zeng-Ling on mouse erythrocyte immunological function and Natural Killer（NK） cell activity. MATERIAL AND METHODS： The ratio of RBC-CR rosette,the ratio of RBC-IC rosette,the ratio of RBC-Ca rosette and NK cell activity were determined. RESULTS： Experiments showed mice erythrocytes could immunologically adhere to tumor cells. After peritoneal injection of cyclophosphamide, the ability of mice erythrocytes adhering to tumor cells was declined,Mian-Zeng-Ling could opposed this action, improving the adherent ability of erythrocytes. The effect of Mian-Zeng-Ling was superior to Zhen-Qi-Fu Zheng grarllies sold in the market. Mian-Zeng-Ling also could oppose cyclophosphamide which reduced mouse NK cell activity, therefore improving and raising the activity of moccse NK cell. CONCLUSION： Mian-Zeng-Ling could improve erythrocyte immunological function and NK cell activity suppressed by cyclophosphamide.