乌梅水煎剂增强大鼠离体子宫平滑肌运动作用的研究

Research the increasing frunction of Fuctus Mume decotion on contractile activity of uterine smooth muscle strips of virginal rats and its action mechanism

目的:探讨乌梅对未孕大鼠离体子宫平滑肌条运动的影响及其机制。方法:用生物机能仪记录子宫平滑肌肌条运动,并分别使用消炎痛(2×10-5mol/L)、酚妥拉明(2×10-6mol/L)、异搏定(2×10-7mol/L)、苯海拉明(2×10-6mol/L)4种阻断剂,观察乌梅水煎醇沉液(以下简称乌梅)对离体子宫平滑肌运动的影响。结果:乌梅能增强未孕大鼠离体子宫平滑肌的舒张运动,使收缩波的频率加快,振幅增大,持续时间延长。结论:乌梅增强未孕大鼠离体子宫平滑肌的收缩运动,该作用主要是通过前列腺素的合成与释放及L型钙通道发挥作用,与H1受体、α受体无关。

AIM： To research the effects of Fructus Mume decotion on contractile activity of uterine smooth muscle strips of virginal rats. Methods： To record the effects of Fructus Mume decotion （2×10^-4 kg/L）on contractile activity of uterine smooth muscle strips of virginal rats with Bio-lap 410 Biological System. Diphenhydramine（2×10^-6 mol/L）, phentolamine（2×10^-6 mol/L）, verapamil （2×10^-7 mol/L）, indomethacin（2×10^-5 mol/L）were used to study effect mechanisms. Results： Water extract of Fructus Mume （2×10^-4 kg/L） could significantly potentiate uterine contractile activity of virginal rats, increase the frequencies, prolong the duration and enlarge the amplitude of contractile activity. Conclusion： The effect of Fructus Mume on contractile activity of uterine smooth muscle strips in rats may be mainly associated with prostaglandin synthese or release and L-voltage-dependant calcium channels, nothing with H1 receptor and αreceptor.