粗叶悬钩子对实验性肝炎小鼠TNFα的影响

Effects of Crude Extract of Rubus Alceaefolius Poir on TNFα ofExperimental Liver Injury in Rats

研究中草药粗叶悬钩子防治肝炎的作用,观察了粗叶悬钩子水煎剂(CERA)对CCL4诱发肝损伤的治疗作用。结果:CERA能降低CCL4所致小鼠血清中异常增高的TNFα含量,且能改善肝脏病理损伤。结论:CERA对小鼠实验性肝损伤有一定的治疗作用。降低TNFα含量,减轻TNFα介导的炎性反应可能是其保护肝细胞的作用机理之一。

To study the prevention and curing effects of crude extract of Rubus alceaefolius Poir （CERA） on experimental liver injury and probing its partial mechanism. In haste liver injury models induced by carbon tetrachloride（CCl4） and interfered by CERA of three different dose to observe the change of the serum TNFα, and the change of pathological tissue slices of liver. Results CERA can significantly decrease the serum of TNFα abnormal high levels induced by CCl4, ameliorate the pathological injure of liver. Conclusion CERA shows some degree of treating effects on experimental liver injury in rats. Decrease the serum of TNFa may be one of its partial mechanism.