原发性不孕症脱落细胞ER、PR与雌、孕激素的相关性研究

Contrasted Study on ER & PR of Exfoliated Cells to Sexual Hormones in Primary Infertility

探讨不孕症雌、孕激素与舌、阴道上皮细胞雌、孕激素受体表达的相关性,及其对鳞状上皮细胞调节机理。选择70例原发性不孕症妇女作为观察对象,采用雌、孕激素及雌、孕激素受体(ER、PR)为指标进行观察。结果:月经周期第10d观察组E2、P较高(P<0.01),第20d观察组P、P/E2较对照组低(P<0.01);月经周期第10d观察组舌苔上皮细胞和阴道上皮细胞PR阳性指数显著高于对照组(P<0.01),第20d观察组ER阳性指数显著高于对照组(P<0.01);舌苔上皮细胞ER与P显著负相关(P<0.05),阴道上皮细胞ER与P、P/E2显著负相关(P<0.05),舌苔上皮细胞ER、PR分别与阴道上皮细胞ER、PR非常显著相关(P<0.01)。结论:ER、PR与雌、孕激素周期性变化有关,参与了激素对脱落细胞的调节。

To study the relationship between estrogen（F-a）, progestin（P） and ER, PR of exfoliated cells,and the regulative mechanisms of E2, P on squarnous cells in primary infertility. The indexes of E2, P, and ER, PR of exfoliated cells in 70 patients with primary infertility were observed. Result： 1. The levels of E2 and P in observation group were higher than control group in lOth day of menstrual cycle（P 〈 0. 01）. P and P/E2 were lower than control group in 20th day of menstrual cycle（P〈0.01）. 2. The PR indexes of tongue and vagina cells in observation group were higher than control group in 10th day（P 〈 0.01）, and the ER indexes were higher than control group in 20th day（P〈 0.01）. 3. The ER indexes of tongue ceils were negatively related to P（P 〈 0.05）, and the ER indexes of vagina cells were negatively related to P and P/E2 （P 〈 0.05）. The ER and PR of tongue cells were closely related to ER and PR of vagina cells（P 〈 0.01）, Conclusion： ER and PR are related to the periodical changes of sexual hormones, which take part in the regulation of exfoliated cells.