磺胺甲基异噁唑在中国明对虾体内的残留和消除规律

The Residues and Elimination of Sulfamethoxazole in Chinese shrimp Fenneropenaeus chinensis

在（20±2）℃水温条件下，研究磺胺甲基异噁唑在中国明对虾肌肉、血淋巴和肝胰脏3种组织中的残留及消除规律。药物在对虾肌肉、血淋巴、肝胰脏中的残留用二氯甲烷提取，反相高效液相色谱法检测，最低检测限可达0．01μg/mL，平均回收率为80％～90％。研究结果表明：磺胺甲基异噁唑在中国明对虾血淋巴中的残留量最小，在肝胰脏中的残留量最大且消除较慢，差异明显。建议把对虾的肝胰脏作为该药残留监控的靶组织，相应的休药期至少为20d。

The residues and elimination of sulfamethoxazole（SMZ） were determined in muscle, haemolymph and hepatopancreas of Chinese shrimp Fenneropenaeus chinensis administrated orally at（20 ± 2）℃ .The medicine was distilled by methylene chloride and its concentration was analysed by High Performance Liquid Chromatography with average recovery of 80% - 90% and the low determination limit of 0.01 μg/ml.The results indicated that the residues and elimination varied among the tissues. There were the maximal residues and minimal elimination in hepatopancreas, and the least residues in the haemolymph. Thus, it is suggested that the hepatopancreas should be the optimal target tissue for SMZ residue.The with - holding period for Chinese shrimp was at least 20 days at water temperature（20 ± 2） ℃ after the shrimp is orally treated at dose of 200 mg/kg with SMZ for 5 consecutive days.