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Sonic Hedgehog在血管新生中的作用 被引量：1

Functions of Sonic Hedgehog in Angiogenesis
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摘要 Sonic Hedgehog介导的信号传导通路是血管生成中一个重要调节环节,可调控血管直径加粗、变长和分叉,影响基质细胞分泌众多的血管新生因子以及动脉血管的发生。Sonic Hedgehog可能通过3种机制(COUP-TF Ⅱ、SHH／GLI／SMO、P13K通路)调控血管生成,并有望成为血管新生研究的新靶向因子。 Sonic Hedgehog signaling pathway is an important regulating phase in angiogenesis, Sonic Hedgehog could regulate the length, diameter and branching of vessels, Sonic Hedgehog could act upon interstitial mesenchymal cells to secrete an array of angiogenic growth factors and induce the morphogenesis of arterial vessels. Sonic Hedgehog could regulate angiogenesis through three different mechanisms （COUP-TF Ⅱ , SHH/GLI/SMO and PI3K pathways） , and it may become a new potential targeting factor in the research of angiogenesis.
作者 罗昭华 修瑞娟
机构地区 中国医学科学院
出处 《医学分子生物学杂志》 CAS CSCD 2005年第6期430-432,共3页 Journal of Medical Molecular Biology
基金 中国科学院知识创新工程项目(No.KJCX1-SW-07)
关键词 Sonic HEDGEHOG 血管新生 肿瘤 Sonic Hedgehog angiogenesis tumor
分类号 R730.23 [医药卫生—肿瘤]
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参考文献21

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同被引文献26

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医学分子生物学杂志
2005年 第6期

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