ACTH(1-24)的应用研究进展

Advances in the Research of ACTH (1-24)

失血性休克是临床上最常见的休克类型。促肾上腺皮质激素(adrenocorticotrphin,ACTH)的N端24肽[ACTH(1-24)]通过迷走神经抗炎通路的激活能快速、高效地发挥抗休克作用,并能降低休克的炎性连锁反应及显著减轻休克后器官的损伤和功能障碍,这将为新型药物的开发和急性失血性休克的治疗开辟新的领域。

Hemorrhagic shock is the most common type of shock in clinical practice. The adre- nocorticotrophin fragment 1-24 [ ACTH （ 1-24 ） ] can effectively and quickly reverse hemorrhagic shock through the activation of a vagal anti-inflammatory pathway and suppression of inflammatory cascade thereby reducing the consequent damage and functional impairment of organs. It will open a new frontier for the development of novel medicines and research of hemorrhagic shock therapy. This article reviews the action and mechanism of ACTH （1-24） in reversing hemorrhagic shock.