通窍活血汤对脑缺血大鼠脑组织中CGRP、ET、IL-1β、TNF-α的影响

Effects of Tongqiao Huoxue Decoction on contents of CGRP、 ET、 IL-1β、TNF-α in the brains of rats of cerebral ischemia

目的:探讨通窍活血汤对脑缺血大鼠脑损伤的保护作用及机制。方法:采用大鼠颈总动脉注入混合血栓诱导剂(ADP、凝血酶、肾上腺素)所致脑血栓加双侧颈总动脉结扎所致脑缺血模型,观察脑缺血后通窍活血汤对脑组织中CGRP、ET、IL-1β、TNF-α的含量变化的影响。结果:通窍活血汤能降低脑缺血大鼠脑组织中ET、IL-1β、TNF-α的含量,增加CGRP的含量。结论:通窍活血汤对脑缺血大鼠脑损伤有保护作用,其保护作用与降低脑缺血后脑组织中异常升高的ET、IL-1β、TNF-α含量、增加脑组织中CGRP的含量有关。

AIM： To investigate the protective effects and mechanisms of Tongqiao Huoxue Decoction on the rats of cerebral ischemia. METHODS： Cerebral ischemia madel was established on the basis of cerebral thrombus and at the same time ligaturing bilateral carotid arteries. These models were used to observe the protective effects of Tongqiao Huoxue Decoction on contents of CGRP,ET,IL-1β、TNF-α in rats＇ cerebral ischemica. RESULTS： The results showed that Tongqiao Huoxue Decoction decreased the contents of IL-1β、TNF-α, ET, and increased the contents of CGRP. CONCLUSION： Tongqiao Huoxue Decoction had effects on anti-cerebral ischemia. The protective effects of Tongqiao Huoxue Decoction are related to decreasing the contents of IL-1β、TNF-α, ET, and increasing the contents of CGRP.