辛伐他汀对急性冠脉综合征患者CRP、vWF、血脂水平及凝血系统的影响

Effects of Simvastatin on Plasma Levels of CRP,vWF,Lipid and Coagulative System in Patients with Acute Coronary Syndrome

目的观察辛伐他汀对急性冠脉综合征(ACS)患者C反应蛋白(CRP)、血管性假性血友病因子(v WF)、血脂水平及凝血系统指标的影响,探讨其非调脂作用。方法随机选取48例ACS患者,其中23例高脂血症患者为血脂紊乱组,口服辛伐他汀40mg/天,治疗12周,25例血脂正常患者为正常对照组,测定血脂紊乱组治疗前后CRP、v WF、血脂和凝血系统指标的变化。结果与治疗前比较,治疗后的CRP、v WF、TC、TG、LDL-C、Fib均显著降低(P<0.01),HDL-C、PT明显升高(P<0.05),TT、APTT显著延长(P<0.01)。且治疗后v WF、TT、APTT与正常对照组有显著性差异(P<0.05)。结论辛伐他汀治疗ACS患者,在有效调脂的同时可显著降低CRP和v WF水平,改善凝血系统功能,有利于动脉粥样硬化斑块的稳定。

Objective: To object the effects of Simvastatin on plasma levels of CRP,vWF,lipid and coagulative system in patients with acute coronary syndrome.Method: 48 patients of acute coronary syndrome were randomly assigned.23 hyperlipidemic patients were asigned to disorder lipidemic group. 25 normal lipidemic patients were asigned to normal lipidemic group.The disorder lipidemic group was given Simvastatin 40 mg/d. The total period of treatment was 12 weeks. CRP, vWF, lipid and coagulative system were determind in disorder lipidemic group of pretreatment and in two groups after 12 weeks.Results: CRP,vWF,TC, TG, LDL-C, Fib were decreased significantly(P<0.01)after 12 weeks. HDL-C, PT,TT,APTT were increased significantly (P<0.05). Compared with normal lipidemic group, vWF, TT, APTT changed significant (P<0.05).Conclusion: Treatments with Simvastatin could reduce the levels of CRP and vWF,and improve the function of coagulation system by toth non-lipid-lowering and lipid-lowering effects, thus it promote the stabilization of atherosclerotic plaque.