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血管内皮生长因子和新生血管在非小细胞肺癌中的表达及其意义 被引量：2

Expression and relation of vascular endothelial growth factor and angiogenesis in non-small cell lung cancer.
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摘要 目的研究血管内皮生长因子(vascu lar endothelial growth factor,VEGF)和新生血管在不同分期非小细胞肺癌(non-sm all cell lung cancer,NSCLC)中的表达及其相互关系。方法共收集79例原发性NSCLC手术标本和12例尸检正常肺组织,用免疫组织化学法(S-P法)检测,用免疫组化图象分析系统进行结果处理。结果非小细胞肺癌中VEGF和新生血管的表达水平与正常肺组织相比差异具有显著性(P<0.05);Ⅰ期与Ⅱ期及Ⅲ期之间相比,VEGF和新生血管的表达水平差异同样具有显著性,并且随分期越晚表达越强(P<0.05);不同细胞类型之间的差异无显著性(P>0.05)。结论VEGF的表达水平与新生血管的表达成正相关。 Objective To evaluate the expression and relation between VEGF and angiogenesis in different stages of non - small cell lung cancer. Methods The expression of VEGF and angiogenesis were detected using immunohistochemical method in 79 lung cancer tissue and 12 normal tissue. The result was analyzed with immunohistochemical image - analysis system. Results VEGF and angiogenesis in NSCLC were significantly higher than that in normal pulmonary tissue. The expression of VEGF and angiogenesis was closely related to P - TNM stages, but there was no difference between adenocarcinoma and squamouscarcinoma. Conclusion A positive correlation was found between VEGF and angiogenesis in NSCLC.
作者 李泽树 杜俊峰 杨世疆 朱佳龙 魏育涛 朱志军 罗波
机构地区 石河子大学医学院第一附属医院心胸外科
出处 《现代肿瘤医学》 CAS 2005年第6期748-750,共3页 Journal of Modern Oncology
关键词 非小细胞肺癌 新生血管 内皮细胞生长因子 NSCLC angiogenesis VEGF
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献16

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共引文献30

同被引文献18

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引证文献2

二级引证文献10

现代肿瘤医学
2005年 第6期

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