食管鳞癌组织中STAT 3蛋白的表达及临床意义

Expression and significance of STAT3 in esophagealsquamous cell carcinoma

目的探讨食管鳞癌组织和癌旁正常黏膜组织中信号转导子和转录激活子3(STAT 3)的表达及与食管鳞癌发生发展的关系。方法应用免疫组化SP法检测122例食管鳞癌及其癌旁正常黏膜组织中STAT 3蛋白的表达。结果食管鳞癌组织中STAT 3蛋白表达阳性率为89.3%,明显高于癌旁正常黏膜组织的77%(P<0.05)。Ⅰ级、Ⅱ级、Ⅲ级食管鳞癌组织中STAT 3蛋白的阳性率分别为73.7%、89.5%和100%,Ⅲ级中STAT 3蛋白的阳性率显著高于Ⅰ级(P<0.05)。浸润至深层(深肌层和外膜)的食管鳞癌组织中STAT 3蛋白阳性表达率为92.8%,明显高于浸润至浅层(黏膜和浅肌层)食管鳞癌组织的76%(P<0.05)。STAT 3的表达与淋巴结转移无关(P>0.05)。结论STAT 3蛋白过度表达与食管鳞癌的发生发展及恶性演进有关,STAT 3有望成为评估食管癌预后的一个新标志物。

Objective： To investigate the expression of signal transducers and activators of transcription 3 （STAT3） in esophageal carcinoma tissues, and discuss the relationship between the expression of STAT3 and the genesis of esophageal squamous cell carcinoma. Methods： SP immunhistochemistry was used to detect the expression of STAT3 in 122 cases of esophageal carcinoma tissues and normal mucosa tissues. Results ： Positive statining rate for STAT3 was 89.3% in esophageal carcinoma tissues, while only 77% in normal mucosa, resulting in a significant difference between total esophageal carcinoma tissues and normal mucosa （P〈0.05）. The expression of STAT3 was higher in poor differentiated esophageal carcinoma tissues than in well differentiated esophageal carcinoma tissues and the depth of the cancer invasion more bigger, the positive staining rate in esophageal carcinoma tissues more higher. No obvious difference of STAT3 expression was detected between lymph node metastatic esophageal carcinoma tissues and in non-lymph node metastatic esophageal carcinoma tissues. Conclusion： The expression of STAT3 may contribute to the genesis and progression of esophageal carcinoma, and STAT3 may be a potential marker for evaluating the prognosis of esophageal careinorma.