牡丹皮镇痛抗炎作用的实验研究

Experimental Study on Pain-easing and Anti-inflammatory Function of Moutan Bark

目的:以牡丹皮为研究对象,观察其高、中、低剂量的镇痛抗炎作用。方法:采用热板法和扭体法,观察牡丹皮对小鼠的镇痛作用;以腹腔毛细血管通透性变化和二甲苯所致耳廓肿胀度和抑制率为指标,分析牡丹皮的抗炎作用。结果:牡丹皮使小鼠痛阈延长,醋酸刺激所致的小鼠扭体反应次数减少,抑制醋酸所致的小鼠腹腔毛细血管通透性增高及二甲苯所引起的耳廓肿胀。结论:牡丹皮具有明显的镇痛抗炎作用,以高剂量最佳。

Objective：To observe the pain-easing and anti-inflammatory function of Moutan bark.Method：the hot-boand method and body-twist method were used to observe Moutan bark＇s pain-easing function on rats.The permcability change of celia capillary,auricle swelling degree and resistant rate caused by dimthylphenanthrene were taken as indexes to analyze the anti-inflammatory function of moutan bark.Results：Moutan bark delayed the rats＇ pain threshhold,reduced the times of body twist caused by acetic acid and restrained the growth of the permeability of celia capillary and the auricle swelling by dimethy-phenanthrene.Conclusion：Moutan bark has obvious pain-easing and anti-inflammatory function and the high dosage has the best effect.