酒依赖患者大脑萎缩的CT研究

Cerebral atrophy in alcohol dependent patients measured by computerized tomography

目的研究酒依赖导致大脑萎缩的程度及其因素。方法头部CT检测项目采用最大径线法测量。结果88例酒依赖患者大脑白质萎缩程度:正常者5.7%,轻度者13.6%,中度者52.3%,重度者28.4%。大脑右半球的脑沟数比左半球的多(P<0.05)。大脑萎缩度数与首次住院戒酒年龄、每日饮酒最多次数、酒依赖年数和酒依赖期饮酒量均呈明显正相关。结论①酒依赖会导致广泛性大脑皮质萎缩和白质萎缩,皮质萎缩右脑比左脑重,以顶叶为最重;②提示在酒依赖期间连续大量而又频繁酗酒是酒依赖导致大脑萎缩加重的重要因素。

Objective To study the extent and factors of the cerebral atrophy in alcohol dependent patients. Methods. The items of CT scanning of the head was examined on the layer of their maximum longitude . Results The extents of cerebral white matter atrophy of 88 alcohol dependent patients ： the normal 5.7%, the light degree 13.6%, the medium degree 52.3% , the serious degree 28.4%. The sulei of the right semisphere of the cerebrum were more than those of the left one（ P〈 0.05 ）. The degree of cerebral atrophy is positively correlated to the drinker＇s age at first compulsory abstinence from alcohol, the maximum frequency of daily alcohol consumption, the years of alcohol dependence and the consumption of alcohol during the period of alcoholic dependence. Conclusion ① Alcohol dependence will cause massive cerebral cortex atrophy and white matter atrophy with more serious cortex atrophy occurring in the right semisphere of the cerebrum , The most serious atrophy occurs in the cerebral cortex of the parietal lobes;②The various factors of cerebral atrophy caused alcoholic dependence. may include the following： longer alcohol dependence period, greater consumption of alcohol, during the period of dependence higher frequency of drinking without compulsory abstinence from alcohol.