奎硫平与利培酮对精神分裂症患者认知功能的影响

A comparison analysis on the efficacy of quetiapine and risperidone in cognitive function of schizophrenia

目的比较奎硫平与利培酮对首发精神分裂症患者认知功能的影响。方法将符合条件的46例首发精神分裂症患者随机分为奎硫平组和利培酮组,分别进行8周系统治疗,用阳性与阴性症状量表(PANSS)评估其疗效;用知识、算术、数字符号、逻辑记忆,威斯康辛卡片分类测验等神经心理测验评估认知功能影响。结果治疗后46例患者PANSS总分明显下降,两组之间差异无显著性(均P>0.05);奎硫平与利培酮能显著改善记忆、注意及执行功能,奎硫平组神经心理测试成绩在Stroop2测验、词汇流畅性测验、WCTS正确数分别为(109.76±1.41)分、(19.94±6.32)分、(35.71±6.74)分,而利培酮组分别为(118.79±1.21)分、(15.88±6.48)分、(31.76±5.84)分。两组相比差异有显著性(P<0.05或P<0.01)。结论奎硫平对首发精神分裂症患者的注意及执行功能的改善作用优于利培酮。

Objective To compare the efficacy of quetiapine and risperidone on cognitive function in patients of first-onset schizophrenia. Methods 46 patients with schizophrenia were randomly treated with quetiapine and risperidone for 8 weeks. The therapeutic response was evaluated with the PANSS, knowledge, arithmetic, digital sign, logical memory and WCTS. Results The scores in the PANSS were descended, but there were no statistical differences （ P 〉 0.05 ）. Both quetiapine and risperidone can significantly improve memory, attention and executive function. After treatment,the scores of Stroop test2 ,verbal fluency and WCTS correct numbers in quetiap- ine group were 109.76±1.41 , 19.94±6.32,35.71±6.74 seperately,where these scores in risperidone group were 118.79±1.21,15.88±6.48,31.76±5.84 seperately. There was significant difference between two groups （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Quetiapine is superior to risperidone in attention and executive function.