益苷颗粒剂对大鼠利胆作用的研究

Effect of Yigan Granules on Bile Secretion in Rats

目的观察不同剂量益苷颗粒对正常大鼠胆汁流量的影响。方法将正常大鼠随机分为空白对照组、阳性对照组、中药益苷颗粒剂大、中、小剂量组,做十二指肠插管给药,胆管插管收集胆汁;分段收集胆汁,比较给药前后流量的变化,分析药物对胆汁流量的影响,并测定用药前后胆汁中胆红素含量。结果中药益苷颗粒剂能使正常大鼠胆汁流量增加,且与剂量正相关。结论中药益苷颗粒剂具有利胆和促进胆红素排泄的作用。

Objective To study the effect of Chinese Herb of Yigan Granules in different dosages on bile secretion in rats. Methods The rats were randomly divided into 5 groups： blank control group, positive control group and high, moderate, low dosages of Yigan Granules groups. The medicines were administered through duodenal intubation for the rats. Then the volume of bile were gathered by common bile duct intubations in different time , and the volume of bile and the contents of bilirubin in bile were tested before and after given drugs. Results Yigan Granules increased the bile secretion in a dose-dependent manner and promote the secretion of bilirubin. Conclusion Chinese Herb of Yigan granules has a choleretic effect.