国产头孢噻呋钠的毒性试验

Toxicity Experiment of Ceftiofur Sodium

为了解国产头孢噻呋钠的毒性,进行了小鼠的急性毒性及对鸡的亚慢性毒性试验。结果表明,小鼠肌肉注射头孢噻呋钠,LD50为1 673.02 mg/kg;鸡注射头孢噻呋钠21 d,未发现与药物相关的体征变化,各组间的体重变化无显著性差异;采食量、饮水量随鸡龄增加而增加,平行比较无显著性差异;各阶段鸡的RBC、WBC分类记数(中性粒细胞/N、碱性粒细胞/B、酸性粒细胞/E、大单核细胞/M、淋巴细胞/L)均在正常值范围内,各组间无显著性差异;各组间血清生化值BUN、GPT、ALB也无显著性差异;各组脏器无显著性差异,说明该药毒性较低。

In order to understand the toxicity of national ceftiofur sodium , the acute toxicity of national ceftiofur sodium on mice and the sub-chronic toxicity on chickens were investigated. The results showed that LD50 of national ceftiofur sodium on mice by i. m was 1 673.02 mg/kg, when administrated to chickens for 21 days, the sign of chickens related to the drug were not found, there was no significant difference in weight change between the groups. The water and food consumed by chickens increased gradually, but no significant difference between the groups. RBC counts,WBC counts and differential counts of WBC （ neutrophil/N, basophil /B, eosinophil /E, monocyte /M, lymphocyte /L） were within normal range of chickens, and no significant difference was found between the groups. The difference of BUN,GPT and ALB of chickens in blood between the groups were not significant. It indicated that the toxicity of national ceftiofur sodium was low.