VEGFIL-6在宫颈癌中的表达及其二者的相互关系

The Expression of VEGF and IL-6 in Cervical Cancer and the Relationship between the Two

目的:对不同类型的宫颈癌组织中血管内皮生长因子(vascularendothelialgrownfactor,VEGF)、白细胞介素-6(Interleukin-6,IL-6)的表达进行定量分析,以进一步探讨VEGF、IL-6在宫颈癌发病中的作用。方法:选取宫颈癌石蜡组织标本50例和10例正常宫颈组织作对照,通过流式细胞检测方法测定VEGF、IL-6的相对含量。结果:VEGF在鳞癌、腺癌中的表达明显高于正常宫颈组织﹙P﹤0.01,P﹤0.01),且VEGF在腺癌中的表达明显高于在鳞癌中的表达(P﹤0.05);VEGF在晚期癌中的表达明显高于早期癌中的表达(P﹤0.01)。IL-6在淋巴结转移者的表达明显高于无淋巴结转移者(P﹤0.05),在中低分化组的表达明显高于高分化组的表达(P﹤0.01),﹤40岁者分别与40～59岁者、≥60岁者比较随年龄增加IL-6增高,统计学上有显著意义(P﹤0.01,P﹤0.01)。结论:VEGF、IL-6与宫颈癌的发生有关,并可作为判断宫颈癌恶性程度和评价预后的指标。

To explore the important role of VEGF and/or IL-6 in pathogenesis of the cervical cancer and to analyze the expression of VEGF and IL-6 using the quantitative analysis in variant cervical cancer. Methods： The expression of VEGF and IL-6 was detected by FCM in the tumorous tissues from 50 cervical cancer subjects and 10 normal cervical tissues. Results： The expression of VEGF was significantly higher in squamous cell carcinoma and adenocarcinoma than that in normal cervical tissues （P〈0.01, P〈0.01）. Moreover, the expression of VEGF in adenocarcinoma and ≥ stage II was markedly higher than that in squamous cell carcinoma and ≤stage I （P〈0.05, P〈0.01）, respectively. However, the expression of IL-6 was markedly increased in lymph node metastasis group and low histological differentiation group, compared to the lymph node non-metastasis group and high histological differentiation group （P〈0.05, P〈0.01）, respectively. The expression was higher in the group of patients younger than 40, compared to the patients group with the age of 40 to 59 and over 60 respectively, which was also age-dependent （P〈0.01, P〈0.01）. Conclusions： Both VEGF and IL-6 are involved in the pathogenesis of cervical cancer, and measurement of expression of VEGF and IL-6 may be developed as a means to evaluate the malignant degree and prognosis of cervical cancer.