三棱、莪术对血瘀证模型大鼠血液流变性影响的比较研究

Comparative Study on Effects of Blood-breaking Drugs Sanleng and Ezhu on Hemorheology Indexes in Rats with Blood Stasis Syndrome

目的:比较破血药三棱、莪术对血液流变性影响的异同。方法:随机将动物分成空白对照组、模型组、三棱组(S组)、莪术组(R组)。前两组灌胃白开水,S组、R组分别灌胃100 g/m l三棱、莪术水煎剂,连续10 d。模型组、S组、R组于第10天复制模型。于第11天处死取血测定。结果:与模型组比较,S组不同切变率下全血黏度ηa1、ηa5、ηa30、ηa200均降低,R组只有ηa5、ηa30、ηa200降低,ηa1无变化。S组、R组红细胞变形指数均明显提高,S组平均血小板容积(MPV)明显降低,差异有显著性。S组与R组比较,ηα1、ηa5、ηa30明显降低,MPV显著改变(P<0.05)。结论:三棱、莪术均可影响血液流变学指标,三棱作用优于莪术。

Objective： To compare the effects of blood-breaking drugs Sanleng and Eshu on hemorrheology indexes. Method： Animals were randomized into control group, model group, Sanleng group （S）, Ezhu group（R）. The S group and R group were fed separately with 100 g/ml Sanleng and Ezhu decoction for 10 days. In the 10th day, the model, S group and R group were injected with adrenaline to make blood stasis syndrome model. Each group was killed in the 11th day, the blood was gathered and the hemorrheology indexes were measured. Result： The whole blood viscosity （WBC） of S group reduced significantly in each shear rate ηα1, ηα5, ηα30, ηα200 compared with those of model group, the WBC of R group reduced significantly only in shear rate ηα5, ηα30, ηα200, there was no obvious change in ηα1. The RBC deformability index of S group and R group increased. The mean platelet volume （MPV） of S group declined markedly. The shear rate ηα1, ηα5, ηα30, the MPV of S group reduced significantly compared with those of R group （P〈0.05）. Conclusion： The breaking-blood drugs Sanleng and Ezhu may improve the hemorrheology indexes, and the effect of Sanleng is superior to that of Ezhu.