乙酰水杨酸－聚天冬酰胺棒状药物体外释放的研究

STUDIES ON IN VITRO RELEASE OF ACETYL SALICYLIC ACID-α,β-POLY(3-HYDROXYPROPYL) ASPARMIDE CONJUGATE

以乙酰水杨酸为模型药物，将药物以共价键键合于聚天冬酰胺高分子母体，制成棒伏。体外释放在Ｔｒｉｓ－ＨＣｌ（ＰＨ７．４）缓冲溶液介质中，温度为３７±０．１℃时，其释放初期的释药量为其膜剂的近１／３０，能较好地控制释药初期的“爆释”现象。

The in vitro release of acetylsalicylic acid-α, β-poly(3-hydroxyPropyl) asparmide conjugate was studied. The drug was molded at 60℃ into 20mg rod. In Tris-HCl (PH=7.4) buffer (25ml, 37.0±0.1℃), its daily in vitro release was assayed by UV spectrophotometry at 295nm. The release Profile showed this drug rod released without any initial burst.