摘要
通过N1-(2-呋喃烷基)-N3-羟乙基-5-氟尿嘧啶的Moffatt氧化,再与亚磷酸酯的加成反应合成得到8个新型含环状α-羟基膦酸酯的N1-(四氢呋喃-2-基)-5-氟尿嘧啶衍生物,采用IR,1HNMR,31PNMR,MS和元素分析对其结构进行了表征.
Eight novel 5-fluorouracil derivatives containing the unit of a-hydroxyphosphonates were synthesized via the addition reactions of cyclic phosphates to 1-furanidin-2＇-yl-3-formylmethyl-5-fluorouracil. The structures of the products were confirmed by IR, 1H NMR, 31p NMR, MS spectra and elemental analyses.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2005年第12期1602-1605,共4页
Chinese Journal of Organic Chemistry
基金
武汉市青年科技晨光计划(No.20025001024)
教育部科学技术研究重点(No.02140)资助项目
关键词
5-氟尿嘧啶
α-羟基膦酸酯
抗肿瘤药物
1-furanidin-2＇-yl-5-fluorouracil
cyclic a-hydroxyphosphonates
antitumor drug
