替加色罗治疗内脏高敏感大鼠前后脑脊髓诱发电位的变化

Changes of spinal evoked potentials and cerebral evoked potentials in visceral hypersensitivity rats before and after Tegaserod treatment

目的:观察替加色罗治疗内脏高敏感性大鼠前后的脊髓诱发电位(SEP)和脑诱发电位(CEP)的变化。方法:内脏高敏感雄性大鼠24只分为3组,每组8只,分别给予替加色罗4mg/kg、2mg/kg及生理盐水灌胃,每日1次,共8周,治疗前后记录SEP及CEP,测量各个波的潜伏期及峰间波幅。结果:①治疗后处理组大鼠SEP和CEP的N1、P1、N2、P2的潜伏期明显延长,两处理组治疗前后有明显差异;②治疗后SEP的N1/P1、P1/N2、N2/P2的峰间波幅明显降低,两处理组治疗前后也有明显差异;③治疗后CEP的N1/P1、P1/N2、N2/P2的峰间波幅有降低趋势,但无统计学意义。结论:替加色罗2～4mg/kg治疗内脏高敏感大鼠8周可以降低直肠球囊扩张时的内脏敏感性,应用脊髓和脑诱发电位可以客观记录这种变化,表现为治疗后潜伏期延长及峰间波幅的降低。

Objective： To study the changes of spinal evoked potentials （SEP） and cerebral evoked potentials （CEP） in visceral hypersensitivity rats before and after treated with Tegaserod. Methods： Twenty-four rats with visceral hypersensitivity were divided into 3 groups at randomly（n=8）, which were given 4 mg/kg and 2 mg/kg of Tegaserod and placebo, respectively. Before and 8 weeks after treatment, latencies and peak-to-peak amplitudes of SEP and CEP were recorded. Results： After treated with Tegaserod, （1） there were noticeable prolonging of N1, P1, N2, P2 latencies of SEP and CEP compared with control group and pretreatment groups; （2） there were significant decreasing of N1/P1, P1/N2, N2/P2 peak-to-peak amplitudes of SEP compared with control and pretreatment groups; （3） there were decreasing trend of N1/P1, P1/N2, N2/P2 peak-to-peak amplitudes of CEP compared with control and pretreatment groups, but there was no statistic significance. Conclusions： Tegasrrod （2-4 mg/kg） can efficiently decrease the sensitivity to rectal distention in visceral hypersensitivity rats. SEP and CEP can show the changes, which are man ifested by long lanteneies and low amplitude of SEP and CEP objectivly.