恶性淋巴瘤树突状细胞和CD_(44)V_6的表达

Expressions of dendritic cells and CD_(44)V_6 in malignant lymphoma

目的:研究树突状细胞(DC)及CD44变异体(CD44V6)在恶性淋巴瘤中的表达及其临床意义。方法:应用免疫组织化学SP方法检测56例淋巴瘤患者的淋巴结及10例肿瘤患者非转移淋巴结中DC及CD44V6的表达,对数据进行统计学处理。结果:DC散在分布于淋巴组织之间,与肿瘤细胞密切接触,存时间长于5年组的DC较短于5年组多,差异有显著性(P﹤0.05);临床分期Ⅰ、Ⅱ、Ⅲ期患者的DC均较Ⅳ期增多,差异有显著性(P﹤0.01);DC与增殖细胞核抗原(PCNA)的表达呈负相关(r=-0.267,P﹤0.05);CD44V6在淋巴瘤中可见阳性表达,且阳性率随疾病分期增加而逐渐增高(P﹤0.05)。结论:DC及CD44V6在淋巴瘤的表达不仅可反映淋巴瘤的恶性程度,而且可作为淋巴瘤的预后指标。

Objective： To investigate the expressions of dendritic cells （DCs） and CD44V6 and their clinical significance in malignant lymphoma. Methods： DCs and CD44V6 in normal lymph nodes in 56 malignant lymphoma patients and 10 tumor patients were investigated immunohistochemically by SP method, and the results were analysed statistically. Results： DCs scattered in tumor tissues and in close contact with tumor cells; patients who survived over 5 years had significantly higher DCs than those who survived less than 5 years （P〈 0.05）; DCs in stage Ⅰ、Ⅱ and Ⅲ were superior in numbers respectively to those in stage IV （P 〈 0.01）; DCs were negatively correlated with the expression of proliferating cell nuclear antigen（PCNA） （r=-0.267, P 〈 0.05）; CD44V6 was expressed in lymphoma, which increased with the going up of the disease stage （P 〈 0.05）. Conclusion： The expressions of dendritic cells （DCs） and CD44V6 in malignant lymphoma not only reflect the malignant degree but also indicate the prognosis.