吡喹酮水凝胶栓剂的制备及含量测定

Preparation and Content Determination of Praziquantel Aquogel Suppository

目的:制备吡喹酮水凝胶栓剂,并建立其含量测定方法.方法:以正交试验法筛选基质最佳处方,采用紫外分光光度法测定主药吡喹酮的含量.结果:最佳基质处方为泊洛沙姆P407/P188(15%:20%)、海藻酸钠0.6%、乙醇15%,由此制得的吡喹酮水凝胶栓剂在体温下胶凝,粘度适中;吡喹酮检测浓度在0.2～1.0mg/ml范围内线性关系良好(r=0.9 999),平均加样回收率为(102.44±0.69)%.结论:该处方设计合理,制备工艺可靠,含量测定方法简便、快速、准确.

OBJECTIVE： To prepare praziquantel aquogel suppositories and to establish its assay method. METHOD： The optimal formula of the base was optimized by orthogonal experiment and the content of principal agent -praziquantel was determined by UV spectrophotometry. RESULTS： The optimized formula of the base was as follows, poloxamer P407 ： P188 （15% ： 20% ）, sodium alginate 0.6% and ethyl alcohol 15%, the praziquantel aquogel suppositories prepared in this formula could be jellified under the body temperature with optimal viscosity. Good linear relationship occurred when the detection concentration of praziquantel was within a range of 0. 2～10mg/ml（ r = 0.9 999）, the average recovery of which was （102.44 ± 0.69）%. CONCLUSION： The design of the formula is reasonable; the preparation process is reliable and the method for assaying is simple, fast and accurate.