摘要
目的:制备吡喹酮水凝胶栓剂,并建立其含量测定方法.方法:以正交试验法筛选基质最佳处方,采用紫外分光光度法测定主药吡喹酮的含量.结果:最佳基质处方为泊洛沙姆P407/P188(15%:20%)、海藻酸钠0.6%、乙醇15%,由此制得的吡喹酮水凝胶栓剂在体温下胶凝,粘度适中;吡喹酮检测浓度在0.2~1.0mg/ml范围内线性关系良好(r=0.9 999),平均加样回收率为(102.44±0.69)%.结论:该处方设计合理,制备工艺可靠,含量测定方法简便、快速、准确.
OBJECTIVE: To prepare praziquantel aquogel suppositories and to establish its assay method. METHOD: The optimal formula of the base was optimized by orthogonal experiment and the content of principal agent -praziquantel was determined by UV spectrophotometry. RESULTS: The optimized formula of the base was as follows, poloxamer P407 : P188 (15% : 20% ), sodium alginate 0.6% and ethyl alcohol 15%, the praziquantel aquogel suppositories prepared in this formula could be jellified under the body temperature with optimal viscosity. Good linear relationship occurred when the detection concentration of praziquantel was within a range of 0. 2~10mg/ml( r = 0.9 999), the average recovery of which was (102.44 ± 0.69)%. CONCLUSION: The design of the formula is reasonable; the preparation process is reliable and the method for assaying is simple, fast and accurate.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第22期1710-1712,共3页
China Pharmacy
关键词
吡喹酮
水凝胶栓剂
正交设计
泊洛沙姆
含量测定
Praziquantel
Aquogel suppository
Orthogonal design
Poloxamer
Content dertermination