α—L岩藻糖苷酶对原发性肝癌的诊断价值

Serum a-L-Fucosidase Activity in the Diagnosis of Primary Hepatocellular Carcinoma

原发性肝癌患者血清α—L岩藻糖苷酶的活性明显升高,并随着病情的发展而变化,提示该酶可作为原发性肝癌诊断及监察的一个指标。

We have investigated serum a-L-fucosidase(AFU)in 1093 normal subjects,91 patients with primary hepatocellular carcinoma(PHC)and 200 patients with cirrhosis and other diseases.AFU activity in PHC patients is higher than that in normal subjects and patients with cirrhosis and other diseases.After operative removal of cancer masses,AFU in PHC patients fell into within normal range and elevated again when recurrence occurred.Detections with both a-L-fucosidase and a- fetoprotein were able to raise PHC diagnostic sensitivity up to 94.2%.It is shown that AFU is of important value in the diagnosis of primary hepatocellular carcinoma as well as in the monitoring the development of the disease.