EB病毒抗原诱导CD_8细胞的特异性研究

The specificity of CD_8 cells induced by EB virus antigen

本文进一步探讨了ＥＢＶ（ＥｐｓｔｅｉｎＢａｒｒｖｉｒｕｓ）抗原诱导ＣＤ＿８细胞的特异性。结果表明，用ＥＢＶ抗原不能从ＥＢＶ血清学阴性者诱导出ＣＤ＿８细胞，而从ＥＢＶ血清学阳性者诱导的ＣＤ＿８细胞对ＥＢＶ活化自身Ｂ细胞呈明显的抑制作用，但无明显细胞毒作用，对美洲商陆（ｐｏｋｅｗｅｅｄｍｉｔｏｇｅｎ，ＰＷＭ）活化自身Ｂ细胞无明显作用，且与刀豆蛋白Ａ（ｃｏｎｃａｎａｖａｌｉｎＡ，ＣｏｎＡ）诱导的Ｔｓ细胞对ＥＢＶ活化自身Ｂ细胞的作用完全相反。提示这种ＣＤ＿８细胞在诱导和作用上都具有ＥＢＶ特异性，可能是一种ＥＢＶ特异性Ｔｓ细胞。

Based on previo us results,further studies of the specificity of CD8 cells weretaken. The results sho wed that CD8 cells could not be indueed from EBV(Epstein B arr virus)sero negative ivdividuals with EBV antigen The CDs eells indueed fro m EBV seropositive indi-viduals with EBV antigen had a definite inhibition on EBV activated auto─B cells,but hadno cytotoxicity and no obvious effects on pokeweed mitogen activated auto─B cells.Com-pared with EB V antigen indueed CDs cells,Ts eells indueed by concanavalin A had anoppoite effect on EBV activated auto─Bcells These results suggested that CD8 eells have EBVspecificity in both induction and effectMost probably,the CD8 cells are EBV─specific Tscells.