年轻冠心病患者子女血脂、脂蛋白、载脂蛋白的研究

Lipids,lipoproteins and apolipoproteins in children whose parents had coronary heart disease in young age

本文对５２名父母于４５岁之前患冠心病（ＣＨＤ）的儿童（平均年龄１３±２岁）和６３名父母无ＣＨＤ的儿童（平均年龄１２±２岁），进行了ＴＣ，ＴＧ，ＨＤＬ─Ｃ，ａｐｏＡ─Ⅰ，ａｐｏＢ─１００水平的对比研究。结果显示：父母较早发生ＣＨＤ的儿童，血清ＴＧ，ＴＣ，ａｐｏＢ─１００水平及ＴＣ／ＨＤＬ─Ｃ显著高于对照组；ＨＤＬ─Ｃ，ａｐｏＡ─Ⅰ，ａｐｏＡ─Ⅰ／ａｐｏＢ─１００水平显著低于对照组。以各检测项目作为判别父母是否发生ＣＨＤ的指标具有效高的阳性率（９６％）。儿童期血脂、脂蛋白、载脂蛋白水平与其父母ＣＨＤ发生关系密切，将来发生ＣＨＤ的危险性显著增高，并呈现出一定的家族聚集性。血脂、脂蛋白、载脂蛋白，是儿童期预测、筛选其未来至成年期ＣＨＤ易感性的较好指标。

children(average age 13 ±2 yeals old)whose parents were less than 45years old but suffered from coronary heart disease and 63 children(avenlge age 12±2years oldjwhose parents without coronary heart disease were investigated. The results showedthat children whose parents suffered from coronary heart disease of eariy onset had muchhigher levels of TC,TG,apoB─100 and a higher ratio of TC/DL─C.They had much low-er levels of apoA─I, HDL─C and a lower ratio of apoA─I/apoB─100 When these itemswere applied to discriminat whether their parents got coronary heart diseases or not,a veryhigh positive rate(96%)were fo und. The serum levels of lip ids,lipoproteins andapolipoproteins in children related closely to their parent’s coronary heart disease.Lipids,lipoproteins,especially apolipoproteins in childhood had more discriminative value in pre-dicting and screening coronary heart disease in the adult.