摘要
目的:研究上消化道出血儿童法莫替丁的药动学和药效学。方法:采用高效液相色谱法测定血清中法莫替丁浓度,以DAS 药代动力学程序计算药代动力学参数,24 h 动态胃内 pH 监测来评价药效。结果:上消化道出血儿童首次静脉滴注法莫替丁(0.9 mg·kg^(-1)),t_(1/2)为(1.70±0.80)h,Vd 为(2.01±1.06)L·k^(-1),XL 为(0.54±0.28)L·h^(-1)·kg^(-1);胃内 pH>4的持续时间约为6 h。结论:静脉滴注法莫替丁(0.9 mg·kg^(-1))可显著抑制胃酸分泌,抑酸作用滞后于血药浓度。儿童不同个体间的药动学差异较大。
Objective:To evaluate the pharmacokinetics and pharmacodynamics of famotidine in children with upper gastrointestinal bleeding. Methods: 15 children with upper gastrointestinal bleeding(ranging from 4. 0 to 15.0 years of age and 14. 0 to 45.0 kg in weight)received 0. 9 mg· kg^-linfusion dose of famotidine. Plasma concentrations were determined with HPLC, and pharmacokinetics parameters were calculated with DAS pharmacokinetic program. 24 - h intragastric pH monitoring was performed. Results: One - compartment model - dependent approach was used to characterize the disposition of famotidine. From the data ,the elimination halflife (t1/2)was (1.70 ± 0. 80 ) hours, the apparent volume of distribution ( Vd ) was ( 2. 01 ± 1. 06 ) L · kg^-1 and the plasma clearance (CL) was (0. 54 ± 0. 28 ) L · h^ - 1 · kg^ - 1 The duration of intragastric pH 〉 4 were about 6 hours. Conclusion: The infusion dose of famotidine (0. 9 mg· kg^- 1 ) can inhibit the gastric acid secretion remarkably, but there is a hysteresis between the inhibition effect of famotidine and the plasma concentrations, and there have individual differences in pharmacokinetics parameters of these children.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2005年第11期1314-1317,共4页
Chinese Journal of Pharmaceutical Analysis
关键词
儿童
法莫替丁
药动学
药效学
上消化道出血
children
famotidine
pharmacokinetics
pharmacodynamics
upper gastrointestinal bleeding