摘要
本研究采用ｍｅｃＡ基因阳性的ＭＲＳＡ菌株建立了兔实验性心内膜炎模型。包括：动脉插管术、静脉感染ＭＲＳＡ、分组进行药物治疗、取血、赘生物及脾、肾组织培养及细菌计数。经国产抗ＭＲＳＡ有效药物去甲万古霉素治疗：静脉注射２０ｍｇ／ｋｇ，一天３次，连续给药４ｄ。结果对照组即未给药治疗组培养结果，菌量一般达到１０４ＣＦＵ／ｇ以上，而治疗组在给药后各项指标均为阴性。证明此模型可用于抗ＭＲＳＡ新药体内抗菌作用的评价。
The experimental aortic valve endocarditis caused by MRSA with mecA gene positive was established in rabbits.The main procedures were as follow:1.arteral cannulation;2. intravenously infected with MRSA;3.randomly divided into two groups:one group received medical treatment.the other didn't;4.counted number of organisms in blood.vegetation.spleen and kidney.Animals received treatment by given norvancomycin: i.v.,20mg/kg every 8 hours,for 4 days. Results showed that the number of organisms were 104 CFU/g in non treatment group but no bacterial counts in blood.vegetation. spleen and kidney after treatment.So the model be used for evaluation in vivo activity of new antimicrobial agents against MRSA.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1996年第1期46-50,共5页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金
