阿苯达唑与甲苯达唑对体外培养的猪囊虫作用的组织化学研究

Histochemical Observation on the Effects of Albendazole and Mebendazole on Cysticercus cellulosae in Vitro

比较了在含１００ｍｇ／Ｌ浓度的阿苯达唑或甲苯达唑的培养液中培养７２ｈ后猪囊虫某些组织化学变化。研究结果表明，在２种药物分别作用于猪囊虫后，囊虫组织中的糖原、琥珀酸脱氢酶和三磷酸腺苷酶活性均明显下降；其中阿苯达唑组的糖原反应及２种酶活性均较甲苯达唑组弱。２个用药组酸性磷酸酶活性略减弱，而碱性磷酸酶活性均无明显变化。

By means of histochemical method, a comparative study on the effects of albendazole (Alb) and mebendazole(Meb)on histochemical changes of Cysticercus cellulosae in vitro after exposure to a dosage of 100 mg/L culture medium for 72 h was carried out. The experi ment enclosed three groups:Control group,Alb treated group and Meb treated group. The results showed that the contents of glycogen in tissues of the parasites in the groups treated with Alb or Meb were decreased obviously.The activities of succinate dehydrogenase and adenosine triphosphatase were declined apparently in two drug groups and more markedly in the Alb group than the Meb group.The activity of acid phosphatase was decreased slightly in the two drug treated groups, whereas the activity of alkaline phosphatase did not show apparently changes in the two drug treated groups.