摘要
分析７３例胃癌患者及７３例年龄、性别相匹配的对照组，经胃镜下活检组织的ＨＰ培养及组织学Ｇｉｅｍｓａ染色，以及应用ＥＬＩＳＡ法测定血清抗ＨＰ抗体水平。结果显示，胃癌组ＨＰ检出率为５８．９％，血清高水平抗ＨＰ抗体检出率为６７．１２％，分别与对照组的５３．４２％和５７．５３％比较无差异性。２组各年龄段间比较也无差异。胃癌的不同分布部位及不同的组织学类型与ＨＰ的检出率无明显相关。结论：胃癌是一种多因素的疾病，ＨＰ感染不是胃癌发生的独立或必须因素，某些致癌因素可能在某些特殊ＨＰ菌株感染的基础上或与其共同作用下导致胃粘膜癌变。
In order to assese the relationship between HP infection and gastric carcinoma, we detected the presence of HP with culture and examinated the level of HP serum antibodies(ELISA)in 73 gastric cancer patients and 73 controls matched for age and sex.Patients and controls were selected on referral for gastroscopy.It was showed that the prevalence of HP infection in gastric cancer patients was 58.9% and 53.42% in controls.the high levels of serum antibodies were found in 67.12% of cases and 57.53% of controls. These differences are not statistically significant.Tumor histology and site had no effect on the presence of HP.We conclude that gastric cancer is a multifactorial disease.HP infection is neither only nor necessary for gastric carcino-genesis.Somefactors may cause gastric malignancy with or based on some special HP strain infections.
关键词
幽门螺旋杆菌
胃癌
抗HP抗体
Helicobacter pylori(HP)
gastric cancer
anti-HP antibodies
