黑质区微量注射神经降压素对帕金森氏病大鼠模型的影响

Affect of Microinjection Neurotensin into Substantia Nigra on Parkinson’s Disease Model in Rats

制作帕金森氏病大鼠模型，观察其黑质区注射徽量神经降压素后的效应。结果表明：（１）黑质区注射６－羟基多巴胺２ｌ天后，大鼠出现帕金森氏病的行动迟缓、强直和震颤等三大症状，以及股四头肌肌电图群放电位频率为４～８次／ｓ的动物模型；（２）黑质区注射不同剂量的神经降压素，经过一定时间后，大鼠模型的强直和震颤症状出现不同程度改善，且呈明显量效依赖关系，而其行动迟缓症状改善不明显。提示，黑质区外源性神经降压素具有一定的抗帕金森氏病效应。

he effect of neurotensin(NT)on the niodel of parkinson’s disease were observed by mi-croinjection into substantia nigra. The results showed:(1)Unilateral administration of 6-OHDAin substantia nigra resulted in the appearance of 3 pricipal neurological signs of parkinson’s dis-ease :hypokinesia ,rigidty and tremor.(2)Intrasubstantia nigra administion of NT,in doses rang-ing from 9μg/μl to 36μg/μl,resulted in dose related attenuation of both muscle rigidty andtremor,however,hypokinesia was not significantly affected by the peptide. These results revealselective antiparkinson-like effects of NT in animal models.