摘要
制作帕金森氏病大鼠模型,观察其黑质区注射徽量神经降压素后的效应。结果表明:(1)黑质区注射6-羟基多巴胺2l天后,大鼠出现帕金森氏病的行动迟缓、强直和震颤等三大症状,以及股四头肌肌电图群放电位频率为4~8次/s的动物模型;(2)黑质区注射不同剂量的神经降压素,经过一定时间后,大鼠模型的强直和震颤症状出现不同程度改善,且呈明显量效依赖关系,而其行动迟缓症状改善不明显。提示,黑质区外源性神经降压素具有一定的抗帕金森氏病效应。
he effect of neurotensin(NT)on the niodel of parkinson’s disease were observed by mi-croinjection into substantia nigra. The results showed:(1)Unilateral administration of 6-OHDAin substantia nigra resulted in the appearance of 3 pricipal neurological signs of parkinson’s dis-ease :hypokinesia ,rigidty and tremor.(2)Intrasubstantia nigra administion of NT,in doses rang-ing from 9μg/μl to 36μg/μl,resulted in dose related attenuation of both muscle rigidty andtremor,however,hypokinesia was not significantly affected by the peptide. These results revealselective antiparkinson-like effects of NT in animal models.
出处
《基础医学与临床》
CSCD
1996年第2期61-64,共4页
Basic and Clinical Medicine
基金
山东省卫生厅研究基金