消炎痛对内毒素肺损伤肺间质液体平衡的影响

The effects of indomethacin on pulmonary interstitial fluid balance after the endotoxin-induced lung injury

本文利用绵羊一肺淋巴瘘一内毒素肺损伤模型，观察了消炎痛对内毒素肺损伤肺间质液体平衡的影响。结果表明，消炎痛可明显阻止内毒素所致的肺微血管压增高、血浆－淋巴胶体渗透压差减小和肺微血管滤过系数增大，从而使肺淋巴流量减少，继而减轻肺水肿。同时还提示，消炎痛对不同阶段的肺淋巴流量具有不同的影响。

The effeets of indomethacin on pulmonary interstitial fluid balance after theendotoxin- induced lung injury were observed using a sheep model. The results showed thatindomethacin could prevent the pulmonary microvascular pressure from rising,the difference of colloidosmotic pressure between the plasma and the lymph from decreasing and the filtiation coefficient ofpulmonary microvessels from increasing. Therefore it attenuated the pulmonary edema by decreasingthe lymph flow,The results also suggested that during ditferent phases of 6-hour experimentindomethacin had different effects on lung lymph flow.