缺氧大鼠肺组织氧化／抗氧化平衡的变化及其与TXA_2／PGI_2平衡的关系

Change of oxidstion/antioxidation balance in lung tissue and its effect on TXA_2/PGI_2 balance in hypoxic rats

检测缺氧大鼠肺组织丙二醛（ＭＤＡ）、超氧化物歧化酶（ＳＯＤ）和过氧化氢酶（ＣＡＴ）含量以及血浆ＴＸＡ＿２和ＰＧＩ＿２浓度，以探讨氧自由基（ＯＦＲ）及ＴＸＡ＿－ＰＧＩ＿２在缺氧性肺动脉高压中的作用。结果表明：与对照组比较缺氧大鼠肺组织ＭＤＡ明显升高、ＳＯＤ、ＣＡＴ明显降低，ＶｉｔＥ可逆转ＭＤＡ和ＳＯＤ的变化；缺氧大鼠血浆ＴＸＢ＿２高于对照组，其浓度与肺组织ＭＤＡ含量呈正相关（ｒ＝０．６５．Ｐ＜０．０５）。以上结果提示，ＯＦＲ与ＴＸＡ＿２／ＰＲＩ＿２平衡失调相互作用，可能共同参与缺氧性肺动脉高压的发生。

To expfore the role of oxygen free radicals(OFR)and TXA2 / PGI2 in hypoxicpulmonary hypertension,the content of lung tissue malondialdehyde(MDA), superoxide dismutase(SOD)and catalase(CAT) and the concentration of plasma TXB2,and 6-keto-pGF1α were deter-mined. It was found that in lung tissue MDA Ievel was increased signiflcantly and SOD,CATcontents were decreased markedly in hypoxic rats as compared with the control group.vitamine E showed some inhibitory effed on changes of SOD and MDA. The level of plasmaTXB2 in hypoxic rats was higher than that of the contiol gloup,and the concentration was positive-ly correlated with lung tissue MDA content(r=0.65,P<0.05). These results suggestal that there wasa synergic action betwren OFR and TXA2-PGI2 which might play an important role in thepathogenesis of hypoxic pulmonary hypertension.