摘要
检测缺氧大鼠肺组织丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)含量以及血浆TXA_2和PGI_2浓度,以探讨氧自由基(OFR)及TXA_-PGI_2在缺氧性肺动脉高压中的作用。结果表明:与对照组比较缺氧大鼠肺组织MDA明显升高、SOD、CAT明显降低,VitE可逆转MDA和SOD的变化;缺氧大鼠血浆TXB_2高于对照组,其浓度与肺组织MDA含量呈正相关(r=0.65.P<0.05)。以上结果提示,OFR与TXA_2/PRI_2平衡失调相互作用,可能共同参与缺氧性肺动脉高压的发生。
To expfore the role of oxygen free radicals(OFR)and TXA2 / PGI2 in hypoxicpulmonary hypertension,the content of lung tissue malondialdehyde(MDA), superoxide dismutase(SOD)and catalase(CAT) and the concentration of plasma TXB2,and 6-keto-pGF1α were deter-mined. It was found that in lung tissue MDA Ievel was increased signiflcantly and SOD,CATcontents were decreased markedly in hypoxic rats as compared with the control group.vitamine E showed some inhibitory effed on changes of SOD and MDA. The level of plasmaTXB2 in hypoxic rats was higher than that of the contiol gloup,and the concentration was positive-ly correlated with lung tissue MDA content(r=0.65,P<0.05). These results suggestal that there wasa synergic action betwren OFR and TXA2-PGI2 which might play an important role in thepathogenesis of hypoxic pulmonary hypertension.
出处
《中国病理生理杂志》
CSCD
北大核心
1996年第2期168-171,共4页
Chinese Journal of Pathophysiology
关键词
游离
前列腺素
抗氧剂酶
缺氧症
Free radicals. prostaglahdins .Antioxidants. Anoxia