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MMP-2、MMP-9和TIMP-1在胃癌组织中的表达及其与临床病理特点和预后的关系 被引量：1

Relationships between expressions of MMP-2,MMP-9,TIMP-1 in gastric carcinoma and pathological characteristics and prognosis
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摘要 目的:探讨基质金属蛋白酶(MMP-2、MMP-9)和金属蛋白酶组织抑制剂(TIMP-1)在胃癌中的表达及与临床病理特点和预后的关系。方法:应用免疫组织化学技术和形态定量分析方法。结果:MMP-2、MMP-9在胃癌基质中有表达,明显高于癌旁正常组织(P<0.01);TIMP-1分布于癌巢周边的基质中;MMP-2、MMP-9及TIMP-1在胃癌中的表达程度与患者的年龄、肿瘤大小、病理分级无关,而与患者的淋巴结转移情况相关(P<0.05)。结论:MMP-2、MMP-9和TIMP-1与胃癌的临床病理特点和转移预后密切相关,可作为判定胃癌生物学行为和预后的重要指标。 Objective To study the relationships of expressions of MMP-2, MMP-9, TIMP-1 in gastric carcinoma and pathological characteristics in clinic metastasis and prognosis. Methods Immunohistochemistry and morphologic quantitative analysis were used. Results Expression levels of MMP-2 and MMP-9 in gastric carcinoma matrix were markedly higher than those of pericarcinoma normal tissues （P 〈 0.01 ）. TIMP-1 expressed in pericarcinoma matrix. There were no any relationships between the expression levels of MMP-2, MMP-9, TIMP-1 in gastric carcinoma and patients＇ age, tumor size, pathological grading, but there was obvious relationship between expression levels of MMP-2, MP-9, TIMP-1 and lymph node metastasis （P〈0. 05）. Conclusion There are close relationships between the expressions of MMP-2, MMP-9, TIMP-1 in gastric carcinoma and pathological characteristics in clinic metastasis and prognosis. They may be used as important indexes to judge the biological behavior and prognosis of gastric carcinoma.
作者 陈永胜 潘留兰 金珍婧 杨力 迟宝荣 李静
机构地区 吉林大学第二医院消化内科 吉林大学第一医院消化内科 内蒙古通辽市人民医院内镜室
出处 《吉林大学学报（医学版）》 CAS CSCD 北大核心 2005年第6期927-930,共4页 Journal of Jilin University：Medicine Edition
基金 吉林省发改委资助课题(2000-9)
关键词 胃肿瘤 明胶酶A 明胶酶B 金属蛋白酶组织抑制剂 stomach neoplasms gelatinase A gelatinase B tissue-inhibitor of metalloproteinase-1
分类号 R735.2 [医药卫生—肿瘤]
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参考文献10

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共引文献8

同被引文献10

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吉林大学学报（医学版）
2005年 第6期

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