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二氢奎尼丁血药浓度测定方法及健康者药代动力学研究

The Method for Derermination of Serecor in Plasma and Study of its Pharmacokinetics in Healthy Volunteers
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摘要 采用反相高效液相色谱法检测二氢奎尼丁血药浓度。二氢奎尼丁最低检测量为10ng/ml,血浆最低检测度为50ng/ml。标准曲线回归方程Y=0.9638X—0.003,相关系数r=0.9982,日内、日间变异度<5.7%。8名健康志愿者口服单剂量serecor 300mg药代动力学研究表明,均符合一室开放模型,且一室、二室间差异不显著。C_(max):0.4637±0.13μg/ml,T_(max):7.72±2.53h,t_(1/2)ka:2.6193±0.96h,t_(1/2)ke:15.4043±10.56h,AUC:12.9646±2.08(μg/ml)·h。 A sensitive RP—HPLC has been developed for the determination of dihydroquiniydine in plasma. The detection limit of dihydroquinidine was 10 μg/L and 50 μg/L in water and in plasma respectively. The standard curve regression equation was y=0.9638x-0.003(r=0.9982). The RSD values of within-day and between-days were lower than 5.70%. The pharmcokinetic parameters of serecor were studied in 8 healthy volunteers after a single oral 300 mg dose. The results showed that the concentration-time curve of serecor was fit to one compartment model. There is no different between one compartment model and two compartment model. C_(max)=0.4637±0.13mg/L. T_(max)=7.72±2.53h. t_1/2ka=2.6193±0.96h. t_1/2ke=15.4043±10.56h. AUC=12.9646±2.08(mg/L)h.
出处 《苏州医学院学报》 1996年第2期201-204,397,共4页 Acta Academiae Medicinae Suzhou
基金 国家八.五攻关项目
关键词 二氢奎尼丁 药物动力学 RP—HPLC, dihydroquinidine, pharmacokinetics
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