S-腺苷高半胱氨酸水解酶及其抑制剂的研究近况

Current Status in Research of S-Adenosylhomocysteine Hydrolase and Its Inhibitors

综述近年来国内外有关S-腺苷高半胱氨酸水解酶分子水平的催化机制及其抑制剂的作用机制研究和产品开发状况。S-腺苷高半胱氨酸水解酶是大多数病毒复制所依赖的细胞酶,它作为广谱抗病毒药物设计的重要靶点,已引起科学家们的广泛关注,其抑制剂的开发目前主要围绕对腺苷类似物的结构改造,以获得高活性、低毒性的抗病毒新药。

The researches of catalytic mechanism of S-adenosylhomocysteine （AdoHcy） hydrolase and acting mechanism of its inhibitors and the related product developing status in recent years were reviewed. AdoHcy hydrolase is the cellular enzyme that plays an important role in most virus replication. Therefore, it has attracted scientists＇ attention as an important target for the design of broad-spectrum antiviral agents. At present, AdoHcy hydrolase inhibitors are mainly developed by modifying the structure of adenosine analogues, so as to obtain new antiviral agents with higher activity and lower toxicity.