超敏CRP及IL-6水平变化在新生儿败血症诊治中的价值

Value of determination of Hs-CRP and IL-6 in blood to diagnose neonate hematosepsis

目的分析超敏CRP及IL-6水平变化,结合中性粒细胞杆状核/分叶核比值、血小板参数等测定,评价其新生儿败血症早期诊断中的价值。方法取35例静脉血测定超敏CRP及IL-6,并作血液分析,超敏CRP测定采用免疫比浊法I、L-6测定采用酶免吸附法,并与对照组比较。结果新生儿败血症时超敏CRP、IL-6、杆状核/分叶核比值、血小板参数与对照组比较有显著差异(P<0.01),治疗前后也有差异(P<0.05)。结论超敏CRPI、L-6、杆状核/分叶核比值、血小板参数水平及动态检测对新生儿败血症的早期诊断及疗效判定具有一定价值。

Objective To analyze the significance of determing Hs-CRP and IL-6 and platelet parameter level in blood, binding the ratio of neutrophic granulocyte band form and neutrophic granulocyte segmentedm form to early diagnose the neonate hematosepsis. Methods The venous blood were obtained in 35 cases with neonatal sepsis and 20 normal neonates for measuring serum Hs-CRP and IL- 6 by immunoassays and then have a blood routine analysis. The changes of serum Hs-CRP and IL-6 were compared before and after the therapy with normal controls. Results There is a significant difference between hematosepsis team and control team in Hs-CRP, IL-6, platelet parameter level and the ratio of neutrophic granulocyte band form and neutrophic granulocyte segmented （P〈0.01）,there is also difference between before and after therapy in the same neonate （P〈0. 05）. Conclusion Dynamically determing Hs-CRP and IL-6 and platelet parameter level in blood, binding the ratio of neutrophic granulocyte band form and neutrophic granulocyte segmentum form have difinite value in early diagno- sing neonate hematosepsis,and helping to judge the therapeutic effect of this disease.