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热休克蛋白与肿瘤细胞凋亡 被引量：2

Heat shock proteins and tumor cell apoptosis
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摘要 热休克蛋白是受各种应激原刺激后诱导产生的一组应激蛋白,具有维持蛋白稳定、促进细胞生存等功能,在细胞生长、发育、分化、基因转录方面发挥重要作用。近年研究对其结构功能有了更深入的了解,热休克蛋白在肿瘤中高表达,与肿瘤细胞增殖密切相关,可通过调控细胞凋亡的线粒体和死亡受体信号转导通路以及应激与生长信号转导通路,抑制肿瘤细胞凋亡。
作者 李霞 邓华瑜
机构地区 重庆医科大学基础医学院病理生理教研室
出处 《国外医学（临床生物化学与检验学分册）》 2005年第11期828-830,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 热休克蛋白质类 肿瘤 细胞凋亡
分类号 R730.2 [医药卫生—肿瘤]
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参考文献15

  • 1Michils A, Redivo M, Zegers-de-Beyl V, et al. Increased expression of high but not low molecular weight heat shock proteins in resectable lung carcinoma. Lung Cancer, 2001, 33(1): 59-67.
  • 2O′Neill PA, Shaaban AM, West CR, et al. Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27. Br J Cancer, 2004, 90(1): 182-188.
  • 3Abe M, Manola JB, Oh WK, et al. Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer. Clin Prostate Cancer, 2004, 3(1): 49-53.
  • 4Barnes JA, Dix DJ, Collins BW, et al. Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia. Cell Stress Chaperones, 2001, 6(4): 316-325.
  • 5Rashmi R, Kumar S, Karunagaran D. Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. Carcinogenesis, 2004, 25(2): 179-187.
  • 6Ravagnan L, Gurbuxani S, Susin SA, et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol, 2001, 3(9): 839-843.
  • 7Park KJ, Gaynor RB, Kwak YT. Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation. J Biol Chem, 2003, 278(37): 35272-35278.
  • 8Mosser DD, Caron AW, Bourget L, et al. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol, 2000, 20(19): 7146-7159.
  • 9Chen F, Chang R, Trivedi M, et al. Caspase proteolysis of desmin produces a dominant-negative inhibitor of intermediate filaments and promotes apoptosis. J Biol Chem, 2003, 278(9): 6848-6853.
  • 10Ochel HJ, Eichhorn K, Gademann G. Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones. Cell Stress Chaperones, 2001, 6(2): 105-112.

同被引文献46

  • 1方永明,董琦,岑辉,唐小萍,郑树.HSF1基因表达升高与大肠癌[J].浙江大学学报（医学版）,2004,33(5):390-394. 被引量：8
  • 2方伟岗.肿瘤细胞侵袭转移的分子生物学基础[J].中华医学杂志,1994,74(7):447-450. 被引量：10
  • 3Nakai A,Tanabe M,Kawazeo Y,et al.HSF4,a new member of the human heat shock factor family which lacks properties of a transcriptional activator[J].Mol Cell Biol,1997,17(1):469-481.
  • 4Sarge K D,Murphy S P,Morimoto R I.Activation of heat shock gene tra-nscription by heat shock factor 1 involves oligomerization,acquisition of DNA-binding activity,and nuclear localization and can occur in the absence of stress[J].Mol Cell Biol,1993,13:1 392-1 407.
  • 5Kim S H,Hur W Y,Kang C D,et al.Involvement of heat shock factor in regulating transcriptional activation of MDR1 gene in mul-tidrug-resistant cells[J].Cancer Letters,1997,115(1):9 214.
  • 6Hoang A T,Huang J P,Rudra-Ganguly N,et al.A novel association between the human heat shock transcription factor 1(HSF1)and prostate adeno-carcinoma[J].American Journal of Pathology,2000,156(3):857-864.
  • 7国家药典委员会.中国药典[S].一部.北京:中国医药科技出版社,2010:附录132.
  • 8Fischer J, Reynolds A J, Shar PLA, et al. Radical carboxyarylation approach to lignans, total synthesis of ( - )-arctigenin, ( - )-matairesinol, and related natural products [ J ]. Org Lett ,2004,6 (9) : 1345-1353.
  • 9Chen GR, Cai LP, Dou DQ, et al. Synthesis of ( -)- arctigenin derivatives and their anticancer activity [ J ]. Nat Prod Res ,2012,26 (2) : 177-181.
  • 10Yoo JH, Lee H J, Kang K, et al. Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling [ J ] . Food Chem Toxicol, 2010,48 ( 8-9 ) : 2247 -2252.

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国外医学（临床生物化学与检验学分册）
2005年 第11期

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