胺碘酮与毛花苷治疗心衰伴快速房颤短时疗效比较

Clinical Observation of Intravenous Amiodarone versus Lanatoside in Treatment of Rapid Ventricular in Patients with Atrial Fibrillation and Congestive Heart Failure

目的:比较静脉应用胺碘酮与毛花苷治疗充血性心力衰竭(CHF)伴快速心室率心房颤动(Af)患者的短时疗效。方法:60例CHF伴快速心室率Af患者,随机分为胺碘酮组30例、毛花苷组30例,在常规治疗基础上,两组分别静脉应用胺碘酮及毛花苷,观察用药后不同时刻的心室率变化、药物平均起效时间及不良反应。结果:两组患者用药后心室率均明显下降。与用药前比较均有统计学差异,用药2h后胺碘酮组心室率下降幅度明显大于毛花苷组(P<0.05);胺碘酮、毛花苷组平均起效时间分别为(26．5±12.7)min和(48.9±14.2)min(P<0．01);胺碘酮、毛花苷组治疗总有效率分别为80.0%和70.0%(P> 0.05)。结论:静脉应用胺碘酮治疗CHF伴快速心室率Af短时效果显著,患者安全性好。

Objective： To evaluate the short - term efficiency of intravenous amiodarone and lanatoside for the treatment of rapid ventricular rate in patients with atrial fibrillation（Af） and congestive heart failure （CHF）. Method： Sixty patients with Af and CHF were randomly divided into two groups. The two groups were introvenously administered amiodarone and lanatoside respectively. Heart rate and the mean response time were measured after the treatment. Adverse effects were recorded. Result： Ventricular rate decreased significant in different time after treatment in two groups, but more significantly in amiodarone group. The mean response time was （26.5 ± 12.7）minutes and （48.9 ± 14.2） minutes in amiodarone and lanatoside groups respectively. No significantly changes of the total effective rate on controlling rapid Af were found between two groups （ 80.0% in amiodarone group versus 70.0% in lanatoside group）. Conclusion： It is efficient and rapid for amiodarone to treat rapid ventricular rate in patients with Af and CHF, and it is well tolerated,