摘要
目的:为临床加温使用注射用七叶皂苷钠提供稳定性实验依据。方法:按临床用药配制七叶皂苷钠-5％葡萄糖注射液混合液,考察在不同温度下放置8 h后药物的外观性状、pH值、紫外吸收图谱、含量及不溶性微粒的变化。结果:在20, 30,35,40,45℃恒温放置8 h,除含量略有下降外,其余各项指标无明显变化。结论:在20-45℃七叶皂苷钠的输液混合液在 8 h内稳定,临床可以加温使用。
Objective： To offer the data of stability of sodium aescinate in injection with heat. Method： Sodium aescinate was prepared with 5% glucose injection, change of appearance, pH, UV spectrum, content, granule at different temperature were studied in 8 h. Result： The appearance,pH, UV spectrum,granule has little change, while the content decline a little at 20,30,35,40,45 ℃ in 8 h. Conclusion： The injection of sodium aescinate is stable between 20 - 45 ℃ in 8 h, and it can be clinical use with heat.
出处
《中国药师》
CAS
2005年第12期1051-1052,共2页
China Pharmacist
关键词
注射用七叶皂苷钠
热稳定性
临床应用
Sodium aescinate for injection
Heat stability
Clinical use
