地塞米松在妊娠期肝内胆汁淤积症治疗中的应用

The usage of dexamcthasone（DX） in the treatment of Inthahepatic Cholestasis of Pregnancy

目的观察地塞米松对妊娠期肝内胆汁淤积症患者的治疗效果及不良反应。方法对64例妊娠期肝内胆汁淤积症孕妇随机分为两组，地塞米松组及对照组各32例。治疗组地塞米松9mg／d，10天后渐减量而停药，14天为一疗程。结果经地塞米松治疗后，患者瘙痒评分，TBA、ALT、AST明显下降（P〈0．01），分娩孕周延长，新生儿体重增加（P〈0．05）。结论地塞米松是治疗ICP安全、有效的药物。

Objective To observe the efficacy and side effects of dexamethasone （DX） in the treatment of intrahepatic cholestasis of pregnancy （ICP）. Methods 64 Pregnant women with ICP were assigned randomly to control group （n = 32） and dexamethasone（DX） group. The DX group receive DX 9mg/d for 10 days, after which the therapy was gradually discontinued over 4 days. Results After the treatment with DX,pruritus. ALT. AST. TBA decreased significantly compared with control group and before treatment （P 〈 0.01）. Meanwhile, both gestational age and weights of infants increased（P 〈 0.05）. Conclusion DX is effective and safe in patients with intrahepatic cholestasis of pregnancy.