笑气联合米索前列醇在人工流产术中临床应用

Clinical Application of misoprostol Before abortion For First-trimester pregnancy with inhaling Nitrous Oxide

目的探讨笑气（N2O）联合米索前列醇在人工流产术中的应用价值。方法将272例初孕妇随机分为笑气组〈A组〉，米索前列醇组〈B组〉，联合组〈C组〉，对照组〈D组〉，观察各组镇痛效果，手术时间与离院时间以及术后有无不良反应。结果4组中任何两组间所观察项目均有显著差异性（P〈0．05或P〈0．01）以联合组效果最佳。结论笑气吸入应用人工流产术镇痛效果确切，联合口服米索前列醇更佳。

Objective To observe the analgetic effect of combining inhaling nitrous oxide and taking misoprostol in surgical abortion. Methods 272 women opting for voluntary surgical abortion were randomly allocated to four groups： nitrous oxide group（A）, misoprostol group （B） combined group and control group （D）. They are observed the operative time. the analgetic effect and the staying time from end of surgery to discharge from hospital. Results There was a significant difference in analgetic effect, the operative time and the stayjng time between each two groups of those four groups （p 〈 0.01 or p 〈 0.05） Among them. the combined group was the best. There was little influence on patients of combined group after surgical abortion. Conclusion It is evident that the analgetic effect by inhaling nitrous oxide and take misoprostol is satisfied in surgical obortion.